{"id":3042,"date":"2021-02-10T16:23:33","date_gmt":"2021-02-10T16:23:33","guid":{"rendered":"http:\/\/www.neurotablet.com\/?p=3042"},"modified":"2021-02-10T16:26:20","modified_gmt":"2021-02-10T16:26:20","slug":"alzheimer-passo-avanti-verso-la-scoperta-dei-meccanismi-sottostanti-la-neurodegenerazione","status":"publish","type":"post","link":"https:\/\/www.neurotablet.com\/?p=3042","title":{"rendered":"ALZHEIMER: PASSO AVANTI VERSO LA SCOPERTA DEI MECCANISMI SOTTOSTANTI LA NEURODEGENERAZIONE"},"content":{"rendered":"\n

Nasce dalla collaborazione tra l\u2019Universit\u00e0 degli Studi di Roma Tre, l\u2019University of Texas Medical Branch e l\u2019Oregon Health & Science University uno studio recente pubblicato su The Journal of Neuroscience con il titolo \u201cOxidative damage and antioxidant response in frontal cortex of demented and non-demented individuals with Alzheimer\u2019s neuropathology\u201d <\/em>[1].<\/p>\n\n\n\n

Lo studio dimostra che individui NDAN (<\/em><\/strong>Non-Demented with Alzheimer Neuropathology<\/em> ) avrebbero la capacit\u00e0 di attivare una risposta cerebrale antiossidante<\/strong> in grado di far fronte alla neurodegenerazione dell\u2019Alzheimer.<\/p>\n\n\n\n

Un punto di svolta importante per la ricerca sui meccanismi sottostanti questa patologia neurodegenerativa che colpisce un numero sempre pi\u00f9 alto di persone. Secondo il Rapporto dell’Organizzazione Mondiale della Sanit\u00e0 e l\u2019Alzheimer Disease International, in Italia oggi il numero totale delle persone<\/strong> affette di demenza \u00e8 stimato in oltre 1 milione<\/strong>, di cui circa 600.000 con demenza di Alzheimer [2].<\/p>\n\n\n\n

I risultati<\/strong><\/p>\n\n\n\n

Lo studio sottolinea il ruolo delle difese antiossidanti contro la neurodegenerazione in particolare nei soggetti NDAN. Analizzando 34 campioni post-mortem di corteccia cerebrale di soggetti di controllo, con alzheimer e NDAN, hanno rilevato come proprio questi ultimi abbiano la capacit\u00e0 di attivare una risposta cerebrale antiossidante che permette di contrastare la neurodegenerazione causata dall\u2019Alzheimer: essi resistono alla demenza<\/strong>, nonostante la presenza di depositi amiloidei e della proteina Tau, caratteristici dell\u2019Alzheimer.<\/p>\n\n\n\n

Tale risposta antiossidante permetterebbe di far fronte allo stress ossidativo, ovvero uno dei meccanismo principali di danno, favorendo la conservazione delle abilit\u00e0 cognitive.<\/strong><\/p>\n\n\n\n

Il prof. Giulio Taglialatela afferma: \u201cNei tessuti dei soggetti NDAN abbiamo scoperto una differente espressione dei fattori che modulano la risposta antiossidante<\/strong>: in particolare, molecole di microRNA regolatrici negative di fattori di trascrizione della risposta antiossidante, sono presenti a basse concentrazioni negli individui NDAN e altamente espresse nei pazienti alzheimeriani\u201d [3].<\/p>\n\n\n\n

Questo studio fornisce ulteriori conoscenze sui meccanismi sottostanti questa patologia e getta le base per nuovi progetti terapeutici per contrastare l\u2019Alzheimer.<\/p>\n\n\n\n

Fonti:<\/strong><\/p>\n\n\n\n

[1] https:\/\/www.jneurosci.org\/content\/jneuro\/early\/2020\/11\/24\/JNEUROSCI.0295-20.2020.full.pdf<\/a><\/p>\n\n\n\n

[2] http:\/\/www.salute.gov.it\/portale\/temi\/p2_6.jsp?lingua=italiano&id=2402&area=demenze&menu=vuoto<\/p>\n\n\n\n

[3] https:\/\/www.uniroma3.it\/articoli\/alzheimer-scoperti-i-meccanismi-delle-difese-antiossidanti-contro-la-neurodegenerazione-138933\/<\/a><\/p>\n\n\n\n

Dott.ssa Denise Magnago, neuropsicologa<\/p>\n","protected":false},"excerpt":{"rendered":"

Nasce dalla collaborazione tra l\u2019Universit\u00e0 degli Studi di Roma Tre, l\u2019University of Texas Medical Branch e l\u2019Oregon Health & Science University uno studio recente pubblicato su [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":3044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[],"tags":[],"class_list":["post-3042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"\nALZHEIMER: PASSO AVANTI VERSO LA SCOPERTA DEI MECCANISMI SOTTOSTANTI LA NEURODEGENERAZIONE - 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Com\u2019\u00e8 possibile che siamo capaci di ascoltare la\u2026","rel":"","context":"In "News"","block_context":{"text":"News","link":"https:\/\/www.neurotablet.com\/?cat=9"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/01\/signora.jpg?fit=1200%2C750&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/01\/signora.jpg?fit=1200%2C750&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/01\/signora.jpg?fit=1200%2C750&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/01\/signora.jpg?fit=1200%2C750&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/01\/signora.jpg?fit=1200%2C750&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":3084,"url":"https:\/\/www.neurotablet.com\/?p=3084","url_meta":{"origin":3042,"position":5},"title":"Attenzione: non possiamo farne a meno!","author":"admin","date":"Giugno 25, 2021","format":false,"excerpt":"Cos\u2019\u00e8 l\u2019attenzione? Com\u2019\u00e8 possibile che siamo capaci di ascoltare la radio e contemporaneamente guidare? Oppure intrattenere una conversazione con un amico in mezzo ad una festa piena di altre persone che chiacchierano e mentre la musica \u00e8 alta? Questi semplici esempi quotidiani ci fanno capire come l\u2019attenzione svolga un ruolo\u2026","rel":"","context":"Articolo simile","block_context":{"text":"Articolo simile","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/12\/attenzione-selettiva.png?fit=1200%2C750&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/12\/attenzione-selettiva.png?fit=1200%2C750&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/12\/attenzione-selettiva.png?fit=1200%2C750&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/12\/attenzione-selettiva.png?fit=1200%2C750&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/www.neurotablet.com\/wp-content\/uploads\/2017\/12\/attenzione-selettiva.png?fit=1200%2C750&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/posts\/3042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3042"}],"version-history":[{"count":1,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/posts\/3042\/revisions"}],"predecessor-version":[{"id":3043,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/posts\/3042\/revisions\/3043"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=\/wp\/v2\/media\/3044"}],"wp:attachment":[{"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurotablet.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}